If some of the infection control measures are neglected, these pathogens may even cause an outbreak in burn units. The care and treatment of these patients have been quite challenging. Patients with severe burns are more prone to infections caused by multiple drug-resistant organisms (MDRO) common examples include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), MDR Pseudomonas spp. , Escherichia coli, and Enterobacter cloacae. The most frequently isolated Gram-negative bacteria from patients with burn wounds include Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella spp. Among that group, Staphylococcus aureus continues to be one of the most important bacterial cause of burn wound infections. The most common Gram-positive bacteria implicated in burn wound infections include Staphylococcus spp., Enterococcus spp., and beta-hemolytic Streptococcus group A.
The microbial colonizers or pathogens affecting burn patients include bacteria and fungi. There are several risk factors which facilitate microbial colonization and infection, including age and comorbidities, burn wound size, impaired immunity (e.g., hyperglycemia, hypermetabolic response), and medical measures (e.g., use of invasive catheters, transfusion, delays in burn wound excision) etc. In burn patients, potential biomarkers can be used clinically to identify infections and sepsis they can also be used to predict the survival of injuries, monitor the severity of injuries, organ function or wound healing.
INFECTED 2ND DEGREE BURN SKIN
Generally, microorganisms will colonize and grow quickly after burns due to the loss of the skin barrier. The extent of TBSA was the most important factor affecting MDRO. The proportion of overall microbial isolates increased with the increase in TBSA and duration of time after burns. For each additional 10% TBSA, the isolation of MDRO increased 2.58–17.57 times ( p < 0.05) for each additional 10% of the third-degree burn severity, the risk of MDRO significantly decreased by 47% (95% CI, 0.38–0.73, p < 0.001) by Cox model.
baumannii (14.6%), followed by methicillin-resistant S. The highest rate of antibiotic resistance was observed in carbapenem–resistant A. ResultsĪ total of 1132 specimens were collected from 37 hospitalized burn patients with mean TBSA of 46.1%.The most commonly isolated species were Staphylococcus spp. Data were collected for a number of variables including severity of burns, demographic and clinical characteristics, laboratory data, and therapeutic devices. This retrospective study was conducted at burn wards and intensive care units, where burn patients were admitted following an event of dust explosion. The purpose of this study was to explore major microbial trends in burn patients. Microbial infection is the main cause of increased morbidity and mortality in burn patients, especially infections caused by multiple drug-resistant organisms (MDRO).
0 kommentar(er)
